Yes very easy. Take the train from Civitevecchia station to Rome. The train station is about 10min walk from the port gates whre you get dropped off by the shuttle bus. Trains run around every half hour and costs 9 euro return. Your train ticket is also valid on all Rome city buses so suggest you get of the train at St Peters (San Pietro) and take the 64 bus from outside the station to St Peters square (2 stops). From there you can do St Peters, Sistine chapel (expect 1 hour queue at least) or take tourist bus around Rome costs around 15-16 euros.
Same as the suggestion from Rugby except ....Go on further than San Pietro to Terminus Station… then walk to Victorio Emanuele Monument, The Capitoline Hill (Piazza del Campidoglio), Trajan’s Column, Roman Forum, Arco di Constantino, Coliseum, Take Metro from Colosseo to Spagna Spanish Steps, Via Condotti, Trevi Fountain Pantheon Piazza Navona... Taxi back to Terminus Station it can be done in a day if you don't go into the Coliseum. Get a map printed off the internet. Great city but watch your pockets....Neil Dow.
Yes ,this is very easy as with most ports.
Walk off the docks,turn right into the town,and walk to the train station.Regular clean trains run into Rome and many other destinations at a fraction of the cost.You will be surprised at the number of fellow passengers doing the same thing.It is very safe and reliable service.On arrival in Rome a first timer could take an open top bus tour around the sites getting on and off the bus at places you wish to look at .The queues at the collusium are usually long.You will have a great day.
Have cruised here myself....absolutely wonderful ....one word of cation....pick pockets are everywhere especially on the 64 bus..!!!!!! beware the people that push a peice of cardboard in front of your chest with words in italian written on it...their accomplice stands next to you attempts to part you and your money,!!! this happened to me while walking in rome.
We went on the Destiny a few weeks ago, did the Rome on your own excursion. This takes you into Rome stopd is a large coach park nr the Vatican, cost £35 each but was well worth not having to worry about independant travel of missing the train. Then caught taxi to Colosseum cost 8 euros then with map provided by tour company walked to all the other landmarks Trevi Fountain, Spanish Steps, Piazza Navona and the Pantheon etc, had 6 hours on our own which was plenty of time to fit in shopping too..then a slow walk back to pick up point